Clinical trial for depressive symptoms in people with Bipolar Disorder or Depression

Deakin University is currently seeking QLD participants for two double-blind RCT’s assessing whether Candesartan improves depressive symptoms in people with either Major Depressive Disorder or Bipolar Disorder. Participation involves a screening process, then six appointments over 16 weeks. Appointments can either be in-person (Toowong Specialist Clinic, in Brisbane), or via Telehealth (if participants are able to attend a QML local to them).

The trial is overseen by Professor Michael Berk at Deakin University. Principal Investigators for QLD participants are Dr Jon-Paul Khoo and Dr Bradley Matthews at Toowong Specialist Clinic.

Inclusion criteria:

• adults (18+) who have a diagnosis of either MDD or Bipolar Disorder, who are currently experiencing a moderate to severe episode of depression
• not diagnosed with a psychotic disorder or current substance use disorder (last 3 months)
• medication stable for at least two weeks (can make changes once in trial)
• not pregnant/breastfeeding/planning to do so whilst on the trial
• not currently having TMS/ECT
• not taking contraindicated medications (including ACE inhibitors, AT1R blockers, diuretics, spironolactone, or daily NSAIDs)
• Systolic BP >110mmHg.

Safety blood tests are taken throughout the trial - results are copied to nominated GP/psychiatrist, but there is no expectation of additional input from treating physician.

If you have patients who may be interested in either of these clinical trials, please direct them to our website.

If you would like further information, please contact:

Sarah Croce - QLD Research Assistant

Mobile - 0481 189 040

Email - sarah.croce@deakin.edu.au

We’d be delighted to provide flyers for distribution or in-clinic display, share them with interested parties, or connect further with you and your team to explore opportunities.